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Firstly, abnormalities in copper metabolism lead to the overactivation of immune cells, especially microglia and peripheral immune cells such as macrophages, monocytes, and neutrophils (168)

BMC Genomics 13:445

DiGeorge syndrome is classically caused by a 22q11.2 microdeletion that disrupts the normal embryologic development of the third and fourth pharyngeal pouches

113 The same researchers then discovered that the mitochondrial targeting sequence-guided gene construct did not recombine with the host mitochondrial genes but rather remained episomal in the mitochondria