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These medications, which include semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), act like the bodys own GLP-1 hormone, but in doses much larger than the body produces, to regulate insulin and blood sugar, decrease appetite, and slow down stomach emptying

Mitochondrial fatty-acid oxidation is a significant source of energy for muscle metabolism, especially during exercise [37]

Regular follow-up appointments should include assessment of patient response, monitoring for adverse effects, and evaluation of the need for dose adjustments

Progress in elucidating hostmicrobiome and microbially mediated metabolic interactions, together with the advent of multi-omics platforms, is poised to significantly advance mechanistic insights into these multifaceted systems

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