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Description

Glutamate-induced neuronal necrosis in the infant mouse hypothalamus

Metformin treatment (100 mg/kg) showed the most significant protective effect, with a marked reduction in lipid accumulation, improved cellular integrity, and minimal evidence of necrosis or other pathological features ( E )

The KD also elicited higher hepatic expression of pro-apoptotic markers, including a 1.8-fold increase in cleaved caspase-3 compared to high-sugar diets and a 2.1-fold elevation in the tumor suppressor protein p21