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Furthermore, to robustly quantify the transcriptomic similarity between tumor cells and myeloid cells, we calculated at single cell resolution multiple metrics, including Manhattan and Euclidean distance metrics, the Cosine and Pearson correlation-based directional similarity metrics, as well as the Phi and Bray-Curtis proportionality and compositional dissimilarity metrics 22,23

Ultimately, these factors create a vicious cycle that contributes to HF

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PLoS One 16, e0260633 (2021), Application(s): High-Content Imager