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Safranal, a monoterpene aldehyde responsible for the characteristic smell of saffron, is an antioxidant that contributes to lowering oxidative stress in the neurons, inhibiting the production of pro-inflammatory cytokines and balancing the equilibrium between free radicals and antioxidants activity (Seyedinia et al., 2023)

Pulmonary transfection of mtDNA by intratracheal instillation induced profound recruitment of neutrophils and expression of proinflammatory cytokines TNF- and KC (an IL-8 homologue) in C57BL/6 mice (Long et al., 2022)

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The aim is to create therapies that act on specific gene loci to control gene expression at the genome level 147