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A large number of clinical samples and animal experiments show that GPX4 levels are significantly decreased in degenerative cartilage tissue, and the degree of its downregulation correlates with the severity of articular cartilage destruction, matrix degradation, and inflammation (Miao et al., 2022

While it effectively bypasses digestion, it introduces higher costs and safety risks compared to oral or topical alternatives

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These compounds are characterized by their low toxicity and limited interactions with conventional drugs