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Some procedures, such as lasers or chemical peels, are not advised during these stages due to safety concerns

It was previously reported that a small part of Trp produced 5-HT through tryptophan hydroxylase (TPH), whereas about 95% of Trp produced KYN through the catalysis of indolamine 2,3-dioxygenase (IDO) or tryptophan2,3-dioxygenase (TDO) (46)