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R.SivakumarM

PMID: 32162795

276 Furthermore, in PASMCs exposed to high oxygen levels, -catenin activation upregulates CTGF and FN1 expression, promoting ECM remodeling and cell proliferation

Recently, several studies have demonstrated that SIRT7 expression is decreased during aging and SIRT7 loss accounts for age-related diseases, such as osteopenia 22 , vascular dysfunction 68 , cardiac hypertrophy 76 , and stem cell aging 23