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doi: 10.1016/s0899-9007(03)00103-5

Estrogen, which provides antioxidant protection at higher levels, decreases during menopause, leaving cells more vulnerable to damage, inflammation, and accelerated aging

Importantly, DP also associates with the RhoGAP ARHGAP32 in epithelial cells, suggesting that the desmosome scaffolds both positive and negative regulators of RhoA to tune contractile signaling (56)

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