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AOD9604 has also been shown to have shown effects on heart disease through fat reduction and weight loss directly reducing the risk of heart disease

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

Cartilage and joint repair models: Intraarticular injection of AOD9604 in a collagenase induced rabbit osteoarthritis model showed improved cartilage architecture and regeneration