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Disordered proteins catalyze redox reactions via a flexible coordination state energetically available for Cu(I) and Cu(II) binding, which is referred to as the in-between state

Statistical analysis Statistically significant differences were assessed by 2-tailed unpaired Student t test or one-way analysis of variance (ANOVA) followed by Tukeys Bonferroni or SNK multiple comparisons test

Introduction Pyrroloquinoline quinone (PQQ) was first reported as a cofactor for bacterial dehydrogenases in the late 1960s [1]

Niacinamide (or nicotinamide) is a biologically active form of niacin (vitamin B 3 ) that has also been shown to inhibit melanosome transfer in a co-culture model of melanocytes and keratinocytes without impairing melanogenesis [137, 138]

Nature 519:9296