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scAAV2-Mediated expression of thioredoxin 2 and C3 transferase prevents retinal ganglion cell death and lowers intraocular pressure in a mouse model of glaucoma

Mechanistically, BL suppresses iNOS expression, stimulates prostaglandin E 2 production, impedes leukocyte migration, and attenuates Toll-like receptor-4 (TLR4)-mediated iNOS upregulation and interferon- (IFN-) secretion (Idelman et al., 2015

There has also been an impairment of histopathological damage and inhibition of NF-kB activation

In this regard, the likely via of cell damage is stratified squamous epithelial cells and filiform papillae, which present ACE2, being infected and progressing to its vicinity causing gustatory cell infection, inflammation, and damage, leading to gustatory system malfunction (Wang et al

Moreover, ebselen increased the expression of GPX2 and GPX4 in SGNs after peroxynitrite injury (Supplementary Figure 3), which is consistent with previous studies that ebselen can increase the expression of GPX2 or GPX4 in rat stomach (Kumar et al., 2010), gastric cancer cells (Xu et al., 2018), or cochlea (Liang et al., 2019)