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There are compounds called reactive oxygen species such as free radicals, peroxides, lipid peroxides, and heavy metals

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For instance, to generate more collagen for the extracellular matrix (ECM), cancer-associated fibroblasts (CAFs) exhibit high proline synthesis rates (116)

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References Acharyya N, Sajed Ali S, Deb B, Chattopadhyay S, Maiti S (2015) Green tea ( Camellia sinensis ) alleviates arsenic-induced damages to DNA and intestinal tissues in rat and in situ intestinal loop by reinforcing antioxidant system