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Women with hormonal drivers (especially around perimenopause and menopause) should also get a hormone evaluation, since addressing underlying hormonal shifts is often part of an effective protocol

Declarations Acknowledgements This work was supported in part by NIA grant R01 AG057381 (Ladiges, PI)

The treatment doubled the relapse-free period

pacificus RSC011 isolate used in this study was frozen within the first 510 generations after original isolation from Coteau Kerveguen on La Runion to minimize domestication and thereby, facilitate the investigation of diet-induced plasticity and TEI

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