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By analyzing three key therapeutic failuresnamely, the unexpected inefficacy of IL-23 pathway inhibition, the dual effects of IL-17 blockade, and the challenges of microbiome-targeted strategieswe aim to elucidate the underlying complexities of AS heterogeneity and tissue-specific immune responses

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Gap19, a mimetic peptide of the Cx43 intracellular loop, inhibits hemichannel opening by suppressing the tailloop interaction without impacting on the gap junction function 514