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Third, the existence of Syn fibrils in a cellular context remains debated 28,29 , as electron microscopy studies shows no clear evidence of -sheetrich amyloid fibrils 22,79

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At the same time, in our previous study on the protective effect of Ebselen on renal ischemia-reperfusion injury, we found that the expression level of GPX3 in renal tissues decreased after renal IRI, and when the level of GPX3 increased after the use of Ebselen, the pathological damage of renal histologic damage was alleviated, and we speculated that GPX3 may play an important role in the oxidative stress response of renal ischemia-reperfusion injury (Wu et al., 2022)

On the other hand, specific formulations, physical characteristics, and lipid differences among the different groups are the reasons for the different classifications