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However, as with any research peptide, animal studies have shown that it can cause potential negative reactions

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It plays an indispensable role in DNA synthesis, red blood cell formation, and neurological function ( Figure 1 Vitamin B12 deficiency, defined as ciculatory B12 level below 150200 pg/mL (borderline 200300 pg/mL) (Figure 2), including megaloblastic anemia and irreversible neurological damage ( Figure 2 For individuals at risk of B12 deficiency, treatment is often necessary to maintain adequate circulatory levels ( Thus, an optimized carrier system is crucial for enhancing the bioavailability of supplemental oral supplemental B12

It is important to note that not all migraine patients are susceptible to the aforementioned nutritional triggers, thus the complete elimination of these items is not always necessary (Mueller 2007)