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Cardiovascular disease in chronic kidney disease: pathophysiological insights and therapeutic options

Downregulated genes were even more conserved, showing 941 genes reduced across all conditions, including core homeostatic microglia genes ( P2ry12 , Cx3cr1 ) and inhibitors of phagocytosis ( Cd33 , Gpr34 ), indicating a highly shared loss of homeostatic identity across models (Fig