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The possibility of sex differences in mitochondrial respiration has garnered much attention and speculation, but a recent meta-analysis, including 2258 participants from 50 studies, demonstrated an overall lack of sex differences 31

Liu C, Tian S, Bai J, et al

This metabolic transformation also results in reduced affinity of the compound for its cellular target

In guinea pigs, the administration of curcumin and encapsulated DEX prior to treatment effectively mitigated the ototoxic effects of cisplatin, thereby safeguarding auditory function across all frequencies