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If binding of one IGF1 molecule to the IGF1R dimer is sufficient for receptor activation, then both the WT:WT and WT:F701A dimers are expected to be active, and the IGF1R activity in cells transfected with WT and F701A plasmids will be 75% of that in cells transfected with the WT plasmid alone

Showed MOTS-c significantly enhanced physical performance in young, middle-age, and old mice, and confirmed exercise induces endogenous MOTS-c expression in human skeletal muscle and circulation