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The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience

doi: 10.1038/s41598-017-01387-y 99 YangP.LiX.YangW.HeL.YangL.ZhangX

circRNF19A-490aa also interacted with HNRNPF, which facilitated recruitment of HNRNPF to the splicing site of AR-V7 and enhanced its alternative splicing