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Lots of drugs or strategies have been developed and applied on clinical trial ( Table 3 ), such as DMARDs, biologic agents, TCM, cell transfer, gene therapy, vaccine and nano drug delivery system, to treat RA with both advantages and shortcomings

Fractional Ablative Variations Some clinics use fractional ablative settings that move closer to a stronger or lighter treatment profile depending on density, depth, pulse settings, and number of passes

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Researchers have developed second-generation skipping drugs, called PPMOs, to enhance targeting and skipping activity