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Roy A, Jana M, Corbett GT et al (2013) Regulation of CREB and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor

To explore alternative therapeutic strategies, we developed a cell-based high-throughput screening (HTS) platform targeting precursor autoprocessing, screened approximately 320,000 small molecules, and identified 27 compounds that partially suppress precursor autoprocessing

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Subsequently, we further verified that -catenin was significantly enriched in the nucleus in NTAPP-exposed hDP cells (Fig