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10.1016/S0378-4347(00)81072-5 130 SongJ.YangX.YanL.-J

Briefly, GH binding to preformed dimeric GHR - JAK2 complexes introduces structural changes in the receptor complex that separates JAK2 inhibitory and kinase active sites and enables trans-phosphorylation of the two JAK2 molecules (reviewed in (59)

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The complete process maintains sterile conditions because it operates in environments which meet Good Manufacturing Practice (GMP) standards