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Since PGC-1 lacks DNA-binding activity, it exerts its regulatory function primarily by binding to and coactivating numerous transcription factors, thereby modulating the expression of genes essential for mitochondrial biogenesis

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Sakamoto J, Miura T, Shimamoto K, Horio Y (2004) Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain