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Ishida, M

The value of GSH as an immunopharmacologic agent is that it can finetune immune response in a disease-dependent and redox state-dependent manner which differs from typical broad-effect immunosuppressive treatments (Figure 3)

These oxygen free radicals lead to lipid, protein, and DNA damage inside cells, which leads to structural and functional abnormalities in periodontal tissues and escalates disease progression

The experimental evidence supporting these mechanisms is compelling

Combined with localized hydrogel delivery and the absence of observable systemic toxicity in vivo, these findings suggest that the administered dose falls within a tolerable safety range