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For example, in vitro bilirubin damages the Raf/ERK/MAPK pathway activation and intracellular levels of Raf and cyclin D1, leading to hypophosphorylation of amino acids S608 and S780 by retinoblastoma proteins, which prevents the release of Yin Yang 1(YY1) into the nucleus and hinders the capability of YY1 to regulate gene expression and support cell proliferation

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

Banu S, Jabir NR, Manjunath NC, et al

A different dose, a different condition, a different patient population