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Studies have shown that long-term treatment with vitamin D promotes GABA synthesis in crucial brain areas such as the prefrontal cortex, anterior cingulate cortex, and hippocampus ( While the -lactam component was intended to increase EAAT2 expression and reduce glutamate toxicity ( Additionally, studies have shown that -lactam antibiotics are associated with improved behavior and neuronal integrity

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Subjects were advised no longer to take any vitamin B-complex, folate, and different dietary supplements in the course of the study and to inform researchers if there was a change in the type or dose of medication used