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One potential reason for the poor long-term benefits of any therapy [for nail fungus] is that it may be treating only a manifestation of underlying disease(s), such as generalized immune suppression or peripheral micro- or macrovascular disease. Maybe fungal nail infections are just a manifestation of poor peripheral blood circulation that would normally allow your bodys natural defenses to keep the fungus from taking root in the first place

One patient in the proactive and two patients in the reactive group died with no death attributed to complications of hyponatremia

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For example, intranasal insulin has been shown to enhance memory and reduce progression of white matter hyperintensity volume over 12 months, supporting its potential as a BBB-bypass therapeutic via olfactory and trigeminal pathways (Kellar et al., 2021)