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Discovered by vonEuler as a demethylated form of adrenaline 10 , NE was identified as a neurotransmitter with agonistic effects on the - and - adrenergic receptors 11

2014 Summer;44(3):241-8

A.RomagnaniP.AshuntantangG.RoncoC.ZarbockA.AndersH

HDAC6 inhibitors such as tubastatin A and the clinically approved ACY-1215 (rocilinostat) enhance aggresome formation and autophagic clearance, reducing tau and -synuclein aggregates in AD and PD models