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344 Yu et al

doi: 10.1021/acsnano.4c18345 118 ZhuDLuoLZengHZhangZHuangMZhouS

Figure 2 shows various factors leading to TBI

Moreover, although the unmethylated CpGs of lipoplex systems are masked preventing an innate immune response, once they are in the general circulation, lipoplex systems may be, similarly like polyplex systems, opsonized by blood proteins (C3, IgG, lipoproteins and fibronectin) resulting in inflammatory reactions (mediated by TNF-alpha, IL-6 and IL- 12) in lungs and liver