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Evidence from preclinical studies consistently supports its role in reducing oxidative stress, suppressing neuroinflammation, and preserving neuronal function in models of Alzheimers disease, Parkinsons disease, and multiple sclerosis

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Targeting AMPK signaling pathway Metformin, an established anti-diabetic medication, has gained attention for its potential therapeutic impact on PH by activating AMPK (Table 1)

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263,264 Apart from intracellular antioxidants like glutathione (GSH), heme oxygenase-1 (HO-1), superoxide dismutase-1, and nicotinamide adenine dinucleotide phosphate (NAPDH), MTs also serve as a redox buffer by interacting with and scavenging reactive species