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Description

Specifically, -Syn exposure suppressed components of the IL-6 signal transducer (IL6ST)/JAK2/STAT3/hypoxia-inducible factor 1 subunit (HIF-1) axis and promoted marked upregulation of multiple ferroptosis-related genes, including transferrin receptor (TFRC), ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1), nuclear factor, erythroid 2like 2 (NFE2L2, most commonly known as Nrf2), ferritin heavy chain 1 (FTH1), glutathione peroxidase 4 (GPX4), and HSP B (small) member 1 (HSPB1)