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Secondary metabolism of aflatoxin B 1 Oxidative metabolism of AFB 1 by cytochrome P450 results in the formation of several products such as AFB 1 -epoxide which serve as substrates for phase II detoxification enzymes

Lactobacillus plantarum ZDY04 exhibits a strain-specific property of lowering TMAO via the modulation of gut microbiota in mice

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ABBREVIATIONS 6-MP 6-mercaptopurine 6-TG 6-thioguanine (6-mercaptopurine and 6-thioguanine) CAO 4-[N-(S-cysteinylacetyl)amino]phenylarsonous acid cAVTP cis-6-(2-acetylvinylthio)-purine CPIC p-chlorophenyl isocyanate DMAC dimethylarsino-cysteine DMACG dimethylarsino-cysteinylglycine EGFR epidermal growth factor receptor GSH glutathione GCAO 4-[N-(S-cysteinylglycylacetyl) amino] phenylarsonous acid GT gamma-glutamyl transferase GSAO [4-(N-(S-glutathionylacetyl) amino)phenylarsonous acid] GS-cAVTP glutathione s-cis-6-(2-acetylvinylthio)-purine Glu glutamate Gly glycine GS-tAVTG glutathione s-trans-6-(2-acetylvinylthio)-guanine PENAO 4-(N-(S-penicillaminylacetyl)-amino)phenylarsonous acid SCPG S-(N-pchlorophenylcarbamoyl) glutathione tAVTG trans-6-(2-acetylvinylthio)-guanine

The authors of the study referenced above showed that GOT1 knockdown caused the accumulation of Gln-derived aKG, indicating that GOT1 may not be important for the production of aKG in PDAC cells