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Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation

Proceedings of the National Academy of Sciences of the United States of America 101:10608-10613

As used herein, the term RibCys refers to 2(R,S)-D-ribo-(1,2,3,4-tetrahydroxybutyl) thiazolidine-4(R)-carboxylic acid, as well as the 2R or 2S enantiomers of (Ia), and its pharmaceutically acceptable salts

Optimal brain function depends on the integrity of neuronal networks, synaptic connectivity, and the balance of neurotransmitters