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There simply arent enough production lines to flex capacity quickly

Structures of amidarone and dronedarone (from Wikipedia Commons)

The series has spawned numerous spin-offs, including a sequel series set in Half-Life 2 that has been ongoing since March 2026

The manufacturer (EMD Serono) voluntarily discontinued Geref in 2008 for commercial reasons, not due to safety concerns

Whereas initial studies suggest that its expression in the proximal tubules is very low, recent studies using microdissected, freshly-isolated, murine, nephronic segments demonstrated the highest IGF-1R mRNA expression in proximal tubules along the nephron [11]