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FIGURE 1 1.2 Nrf2-Keap1-ARE signaling pathway Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor belonging to the Cap n Collar family

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J Anim Behav Biometeorol 6:6271

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For severe cases, biologics and traditional systemic agents like methotrexate, retinoids, and cyclosporine are more common choices (Nakamura & Koo 2020