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Systemic Inflammation in Decompensated Cirrhosis: Characterization and Role in Acute-On-Chronic Liver Failure

Following a comprehensive cellular and cytokine profiling by flow cytometry across distinct immunological niches, we identified CD4 + T cells residing in the dural meninges as a source of disease-associated IL-17A in 5xFAD mice, which was downregulated by targeting CD38, with no effect on IFN-- or IL-4-producing T cells (Fig