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Melatonin-loaded nanoparticles augment mitophagy to retard parkinsons disease

Concurrent reductions occurred in purine/pyrimidine metabolites essential for nucleotide synthesis and energy supply, including guanosine, uracil, adenine, uridine monophosphate (UMP), inosine monophosphate (IMP), and adenosine diphosphate (ADP) (Fig

We hypothesized that another thymic peptide, thymulin, could be similarly produced by non-thymic cells during stress and have a precursor therein

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After 48 h, cultures were treated with 10 M cytosine arabinoside (MCE, Cat#HY-13605) to suppress fibroblast proliferation, followed by a 3-day expansion in growth medium