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Conversion of long-lived and highly diffusible H 2 O 2 into short-lived and locally confined HOCl by MPO thus provides a clever mechanism to specifically target pathogens within the phagosome and effectively protect neutrophil cytoplasm and surrounding host tissue against HOCl-induced oxidative damage

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For example, the AMBITION trial showed that combining ET-1 receptor antagonists with PDE5 inhibitors is more effective than monotherapy

2 , 49 , 50 The MC1R gene exhibits significant polymorphism, with 55 single-nucleotide polymorphisms (SNPs) identified across seven geographically distinct human populations