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Magnesium is essential for normal vascular smooth muscle relaxation, healthy cardiac rhythm, and over 300 enzymatic processes

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By increasing solubility, prolonging circulating half-life, and reducing immunogenicity, PEGylation addresses key limitations that have historically constrained the clinical use of peptides

Technical and biological hurdles are paramount, including the inefficient delivery of cells or vectors to widespread motor neurons across the central nervous system, host immune responses that can limit efficacy or durability, and unresolved long-term safety concerns such as off-target effects or uncontrolled cell differentiation (15, 60, 65)

Various ion/counter ion salt complexes are contemplated for use herein, including, but not limited to, divalent cations such as calcium, potassium, magnesium, manganese, iron, zinc