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These factors highlight that, while glutathione can be an effective skin-lightening agent, especially in its oral or topical forms

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

For skin irritation, itching

Aegilops tauschii genotypes treated with selenite revealed that several key pathwayssuch as phenylpropanoid biosynthesis (ko00940), carbon metabolism (ko01200), fatty acid metabolism (ko01212), and plantpathogen interaction (ko04626)may be involved in Se metabolism

For example, thiolate can nucleophilically attack hydropersulfide to form disulfide and release hydrogen sulfide (H 2 S), which is similar to the reaction of thiolate with sulfenic acid or hydroperoxide (Switzer, 2023)