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Wu L, Bao F, Li L, Yin X, Hua Z

GHK-Cu does not inhibit ghrelin, does not stimulate GLP-1 receptors, and does not meaningfully alter insulin sensitivity

The most completely understood mechanism for targeted removal of damaged mitochondria is through the PINK1 (PTEN-induced kinase 1)-Parkin mitophagy pathway (230)

Microbiota-derived metabolites, including short-chain fatty acids, secondary bile acids, and trimethylamine, can modulate hepatic autophagy ( Autophagy plays a crucial role in maintaining intestinal homeostasis

There is also a potential risk of immune responses to synthetic peptides or genetically modified strains, necessitating dedicated immunological safety assessment (Mousa et al., 2023)