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Environ Sci Pollut Res 20(2):884896

A 36 residues insertion in the dimerization domain of the growth hormone receptor results in defective trafficking rather than impaired signalling

This subsequently activates CaMKII and NADPH oxidase on the cell membrane, which then triggers the release of cytochrome C from the mitochondria, promoting the generation of ROS and apoptotic bodies, thereby initiating caspase-9 mediated apoptosis (Munoz-Pinedo et al., 2006

Schedule Consultation How It Works CJC-1295 and Ipamorelin target different receptors to create sustained, amplified growth hormone secretion