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PMID: 100 GhalyF
Cell Cycle 17 , 16021613
2,4 PATHOPHYSIOLOGY CF is caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene
FSP1 (ferroptosis suppressor protein 1) facilitates the NADPH-dependent reduction of CoQ10 to CoQ10H 2 , a lipophilic radical-trapping antioxidant that prevents lipid peroxidation ( de novo synthesis pathway, works alongside GPX4 to inhibit mitochondrial lipid peroxidation
