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doi: 10.1016/B978-0-444-63432-0.00003-7 180 Orellana-UrzaS.Briones-ValdiviesoC.ChichiarelliS.SasoL.RodrigoR

Mechanistically, the mutant huntingtin protein appears to disrupt cellular iron handling by increasing the expression of iron importers and promoting iron accumulation in neuronal mitochondria [241]

[] Therefore, future studies should focus on bone damage caused by a single liver disease

3.3 Challenges and future directions The translation of stem cell and gene therapies from promise to practice faces a spectrum of interconnected challenges