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Achyranthes bidentum polysaccharide has vital anti-inflammatory and antalgic effects, and can promote chondrocyte proliferation and suppress chondrocyte apoptosis [117]

FIGURE 3 6.1 Anti-hepatic fibrosis effect of curcumin PPAR (NR1C1), a ligand-responsive nuclear hormone receptor, demonstrates pronounced hepatic tissue enrichment, was originally characterized as a pharmacological target for heterogenin that induces peroxisome proliferation in rodents (Issemann and Green, 1990)

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Excessive extracellular glutamate concentration also impacts systemic xc - , preventing cystine entry, which in turn leads to GSH depletion triggering ferroptosis [95]

Nonetheless, rigorous GLP-compliant toxicology, drug-interaction studies, and reproductive healthfocused clinical trials are needed to fully define long-term safety and support its development for gynecologic indications