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Studies using minocycline in light-induced retinal damage models and their impact on microglial cells have varied showing both a decrease in immunolabeling of CD11b of microglial cells, which may protect against loss of photoreceptors through inhibition of retinal microglia activation, and a delay in photoreceptor cell death, which was independent of a reduction in retinal microglial cells, following depletion of microglia cells using liposomal chlodronate (Yang et al., 2009

They are: zinc, copper, manganese, selenium and iron (Halliwell and Gutteridge, 1985)

The generation of ROS leads to lipid peroxidation, mitochondrial dysfunction, and DNA fragmentation, which collectively contribute to cell death in the inner ear (Ramkumar et al