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10 siRNA therapies including olpasiran, zerlasiran, and lepodisiran have demonstrated significant Lp(a) reductions, with olpasiran achieving up to 101.1% placebo-adjusted reduction in the phase 2 OCEAN(a) DOSE trial, lepodisiran up to 97% reduction with the maximal dose in the phase 1 study, 93 and zerlasiran showing a 96.4% reduction in the recently published phase 2 trial

Med Res

Mechanism and Effect of Esculetin in an Experimental Animal Model of Inflammatory Bowel Disease

Several factors, including the individuals age, overall health, geographic location, antibiotic treatment dosage and duration, and specific antibiotics, influence the recovery of the gut microbiota following the antibiotic-induced disruption ( Numerous intestinal bacteria, including Lactobacillus ( Bifidobacterium ( Enterococcus ( Clostridium perfringens , Staphylococcus aureus , or Clostridioides difficile to gain prominence ( Beneficial microorganisms and their mutually beneficial relationship with humans are pivotal in maintaining human health ( This review presents an update on the utilization of probiotics in managing and treating various human diseases, including complications that may emerge during or after a COVID-19 infection