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Julie Wichlin (B12 Bandit) explores this in more depth on her Substack: PAS members can get support understanding their own results through our helpdesk: 20 Years of Education, Research & Support

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38 For example, multiple doses of diltiazem 240 mg extended-release formulation, a strong CYP3A4 inhibitor and P-gp inhibitor, increased C max and AUC of naloxegol by 2.86-fold (90% confidence interval, 2.59, 3.15) and 3.41-fold (90% confidence interval, 3.16, 3.69), respectively

However, the bacterium Enterobacter aerogenes , given as a probiotic, decreased TMAO levels in mice [65]

Moosa MR, Van der Walt I, Naicker S, Meyers AM